What this marker measures
DHEA-S peaks in early adulthood and then declines steadily throughout life. Reference ranges are strongly age-dependent. It is one of the most abundant circulating hormones but its clinical significance in routine testing is still debated.
High or low: what it can mean
High DHEA-S
Elevated DHEA-S in females can be a marker of excess adrenal androgen production, often seen in conditions such as PCOS, congenital adrenal hyperplasia, or adrenal tumors. In males, elevated values can be associated with adrenal dysfunction.
Read full explanation →
Low DHEA-S
DHEA-S naturally declines with age (this is considered normal). In younger individuals, low DHEA-S can reflect adrenal insufficiency, chronic stress, or chronic illness.
Read full explanation →
Frequently asked questions
What is DHEA-S?
+
DHEA-S is an adrenal androgen (male-type hormone) produced by the adrenal glands. It is a precursor to sex hormones and is involved in immune function and energy metabolism.
What does DHEA-S measure?
+
DHEA-S peaks in early adulthood and then declines steadily throughout life. Reference ranges are strongly age-dependent. It is one of the most abundant circulating hormones but its clinical significance in routine testing is still debated.
What does high DHEA-S mean?
+
Elevated DHEA-S in females can be a marker of excess adrenal androgen production, often seen in conditions such as PCOS, congenital adrenal hyperplasia, or adrenal tumors. In males, elevated values can be associated with adrenal dysfunction.
What does low DHEA-S mean?
+
DHEA-S naturally declines with age (this is considered normal). In younger individuals, low DHEA-S can reflect adrenal insufficiency, chronic stress, or chronic illness.
Related biomarkers
Editorial note
LabTestly explains lab markers using plain-English educational content. Reference ranges may vary by laboratory and should be interpreted with a clinician.
Educational content · Editorially reviewed for clarity · Last updated
Common sources used for lab-test education
Not medical advice
This page is for general understanding only and does not replace medical advice from your clinician. Reference ranges can vary by laboratory, age, sex, pregnancy status, medications, and clinical context.