What this marker measures
MCHC is one of the most reliable automated CBC indices. Because it is calculated independently of cell count, it serves as an internal quality check on the other indices.
High or low: what it can mean
High MCHC
A high MCHC (hyperchromia) is uncommon and can be seen with hereditary spherocytosis or severe dehydration. It is usually investigated alongside other CBC findings.
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Low MCHC
A low MCHC (hypochromia) means each red blood cell is less densely packed with hemoglobin than normal, most commonly in iron deficiency.
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Frequently asked questions
What is MCHC?
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MCHC measures the concentration of hemoglobin within red blood cells — essentially how densely packed with hemoglobin each cell is.
What does MCHC measure?
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MCHC is one of the most reliable automated CBC indices. Because it is calculated independently of cell count, it serves as an internal quality check on the other indices.
What does high MCHC mean?
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A high MCHC (hyperchromia) is uncommon and can be seen with hereditary spherocytosis or severe dehydration. It is usually investigated alongside other CBC findings.
What does low MCHC mean?
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A low MCHC (hypochromia) means each red blood cell is less densely packed with hemoglobin than normal, most commonly in iron deficiency.
Related biomarkers
Editorial note
LabTestly explains lab markers using plain-English educational content. Reference ranges may vary by laboratory and should be interpreted with a clinician.
Educational content · Editorially reviewed for clarity · Last updated
Common sources used for lab-test education
Not medical advice
This page is for general understanding only and does not replace medical advice from your clinician. Reference ranges can vary by laboratory, age, sex, pregnancy status, medications, and clinical context.