What this marker measures
Fibrinogen is sometimes included in cardiovascular risk assessments alongside CRP, as chronic low-grade inflammation raises both. It is also a key marker in coagulation disorder work-up.
High or low: what it can mean
High Fibrinogen
Elevated fibrinogen indicates either active inflammation/infection or increased clotting risk. Chronically elevated fibrinogen is considered an independent cardiovascular risk factor.
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Low Fibrinogen
Low fibrinogen (hypofibrinogenemia) can impair blood clotting. Causes include rare genetic conditions, severe liver disease, disseminated intravascular coagulation (DIC), or major blood loss.
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Frequently asked questions
What is Fibrinogen?
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Fibrinogen is a blood-clotting protein produced by the liver. It is converted into fibrin during clot formation and also acts as an acute-phase reactant that rises with inflammation.
What does Fibrinogen measure?
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Fibrinogen is sometimes included in cardiovascular risk assessments alongside CRP, as chronic low-grade inflammation raises both. It is also a key marker in coagulation disorder work-up.
What does high Fibrinogen mean?
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Elevated fibrinogen indicates either active inflammation/infection or increased clotting risk. Chronically elevated fibrinogen is considered an independent cardiovascular risk factor.
What does low Fibrinogen mean?
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Low fibrinogen (hypofibrinogenemia) can impair blood clotting. Causes include rare genetic conditions, severe liver disease, disseminated intravascular coagulation (DIC), or major blood loss.
Related biomarkers
Editorial note
LabTestly explains lab markers using plain-English educational content. Reference ranges may vary by laboratory and should be interpreted with a clinician.
Educational content · Editorially reviewed for clarity · Last updated
Common sources used for lab-test education
Not medical advice
This page is for general understanding only and does not replace medical advice from your clinician. Reference ranges can vary by laboratory, age, sex, pregnancy status, medications, and clinical context.